The medical community have felt for a long while that low serotonin levels in the brain lead to depression — but there are several problems with that belief — and new research suggests neurogenesis holds a truer key to cure.

If it takes up to a month for medicine to increase serotonin levels in the brain, there should still be a recordable difference in mind and mood as serotonin levels increase over.  That was not the case.

Increasing serotonin levels only helped 60% of patients.  If low serotonin levels were the cause of depression, everyone on medication should have seen some beneficial, measurable, outcome.  That was not the case.

If we reverse the theory — by lowering serotonin levels in non-depressed people — we should see an overall increase in depression.  That did not happen.

Anti-depressants increase neurogenesis by creating more cells and by making new neurons in the brain and, more specifically, the hippocampus.

Research is now focusing on increasing neurogenesis — without the side effect current depressive medication creates by increasing neurons — and the promise of this new attack on depression is that we can finally, perhaps, genetically, and permanently, transform the depressive mind into an average one.

2 Comments

    1. David Boles – New York City – David Boles was born in Nebraska and holds an MFA from the Oscar Hammerstein II Center for Theatre Studies at Columbia University in the City of New York. He is an author, dramatist, editor, publisher, and teacher who writes across the live stage, print, radio, television, film, and the web. With more than 50 books in print, David continues to write 2MM words a year and has authored over 25K articles. He is a member of the Dramatists Guild, the Authors Guild, and PEN America, and founded The United Stage advocacy platform on the principle that playwrights have a duty to direct their own work. Read the Prairie Voice Archive at Boles.com | Buy his books at David Boles Books Writing & Publishing at BolesBooks.com | Study with Script Professor at ScriptProfessor.com | Touch American Sign Language mastery at Hardcore ASL at HardcoreASL.com | Explore the Human Meme podcast at HumanMeme.com | Train with Boles Bells at BolesBells.com.
      David W. Boles says:

      I’m with you on that one, Gordon. The research is so exciting and just proves that what we think we know, we might not really know.

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